{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:53:38Z","timestamp":1791896018682,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Accumulating evidence from experimental animal studies is essential for clarifying the causal relationship between exposure to power\u2010frequency magnetic fields (MFs) and childhood leukemia. In this study, we developed a 50\u2009Hz MF exposure system for experimental animals. To ensure uniform whole\u2010body exposure of multiple animals placed at the center of the coil, we fabricated a Merritt\u2010type coil. The maximum MF output inside the coil was 5\u2009mT(rms), and spatial variation remained within \u00b12.5% of the target intensity. The system enabled stable exposure of experimental animals to uniform 50\u2009Hz MFs while eliminating equipment\u2010related artifacts. We then conducted exposure experiments using humanized mice, in which a human\u2010like hematopoietic system was established by transplanting human hematopoietic stem and progenitor cells (HSPCs), to a 50\u2009Hz, 5\u2009mT(rms) MF for 2 months. After exposure, the chimerism rates of human leukocytes in hematopoietic organs of the MF\u2010exposed group were comparable to those in the control group. Furthermore, exposure to the 50\u2009Hz MF did not affect early differentiation of human B cells in the bone marrow of humanized mice. These findings support our previous in vitro results and validate the use of humanized mice for evaluating the effects of power\u2010frequency MFs on human hematopoiesis. This system is expected to evaluate the effects of 50\u2009Hz MFs not only on normal human hematopoiesis in humanized mice but also under abnormal conditions such as preleukemic state induced by transplanting genetically modified HSPCs.<\/jats:p>","DOI":"10.1002\/bem.70054","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:15:32Z","timestamp":1778750132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Effects of 50\u2009Hz Magnetic Field Exposure on the Human Hematopoietic System in Humanized Mice"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3943-0783","authenticated-orcid":false,"given":"Masayuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Sustainable System Research Laboratory Central Research Institute of Electric Power Industry (CRIEPI) Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Sustainable System Research Laboratory Central Research Institute of Electric Power Industry (CRIEPI) Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Toda","sequence":"additional","affiliation":[{"name":"JAC Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1376"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0416-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.111993"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.02.036"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0952-4746\/36\/3\/437"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.22193"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03756-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01880-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.6.1428"},{"key":"e_1_2_8_11_1","first-page":"1294","article-title":"Day Care in Infancy and Risk of Childhood Acute Lymphoblastic Leukaemia: Findings From UK Case\u2010Control Study","volume":"330","author":"Gilham C.","year":"2005","journal-title":"BMJ (London)"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bem.21976"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0015-6"},{"key":"e_1_2_8_14_1","first-page":"120","article-title":"Speculations on the Cause of Childhood Acute Lymphoblastic Leukemia","volume":"2","author":"Greaves M. 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