{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:43:48Z","timestamp":1785840228592,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Magnetic field therapy is a non\u2010invasive, safe, and simple method used to directly treat various diseases and pathologies. The aim of this systematic review is to examine the evidence for the efficacy of bio\u2010electro\u2010magnetic\u2010energy\u2010regulation (BEMER), a magnetic field therapy, in the treatment of musculoskeletal pain. A database search was conducted using the following resources: PubMed, EMBASE, SCOPUS, and WoS. The following search strategy was used and adapted for each database: (\u201cpain\u201d) AND (\u201cBEMER\u201d OR \u201cBEMER therapy\u201d OR \u201cPEMF\u201d OR \u201cbio\u2010electromagnetic energy regulation\u201d OR \u201cpulsed electromagnetic field\u201d OR \u201cvascular therapy\u201d), in accordance with the PRISMA 2020 statement. Randomized controlled trials involving pain assessment in musculoskeletal pathologies, written in English, published between 1 January 1990 and 30 July 2023 were included; cell, animal, and in vitro studies, reviews, and conference proceedings were excluded. The PEDro scale was used to assess the risk of bias. Seven randomized controlled trials were included. Across the included studies, some reductions in pain were reported after BEMER therapy; however, only one of four sham\u2010controlled studies found BEMER to be superior to sham treatment. Considerable heterogeneity was observed in treatment protocols. Overall, the current evidence does not demonstrate that BEMER therapy is more effective than sham\/placebo in reducing musculoskeletal pain. Standardized, high\u2010quality trials are needed to clarify whether BEMER has any specific treatment effect beyond placebo. Bioelectromagnetics. 00:00\u201300, 2026. \u00a9 2026 Bioelectromagnetics Society.<\/jats:p>","DOI":"10.1002\/bem.70057","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:11:11Z","timestamp":1780395071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Bio\u2010Electro\u2010Magnetic\u2010Energy\u2010Regulation Therapy in Musculoskeletal Pain Management: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.1002","volume":"47","author":[{"given":"Makbule","family":"Karc\u0131","sequence":"first","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Science Istanbul Ayd\u0131n University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesli\u015fah","family":"G\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Science K\u0131rklareli University K\u0131rklareli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcstem","family":"Mustafao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Science Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6049-0705","authenticated-orcid":false,"given":"Abdurrahim","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences Sakarya University of Applied Sciences Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengin","family":"Demir","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2020.4975"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2019.0043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/jom-2020-0132"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0754-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2018.1491661"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzy030"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5606\/tftrd.2022.9074"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2022.01.017"},{"issue":"3","key":"e_1_2_9_10_1","first-page":"70","article-title":"Therapeutic Uses Of Low Frequency Electromagnetic Fields","volume":"32","author":"Demirel C.","year":"2015","journal-title":"Selcuk Medical Journal"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"1","article-title":"Bio\u2010Electro\u2010Magnetic\u2010Energy\u2010Regulation: An Astonishing Increase in Blood Flow","volume":"1","author":"Draper D. 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