{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:43:42Z","timestamp":1785840222994,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR23E070001"],"award-info":[{"award-number":["LR23E070001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Bioelectromagnetics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor treating fields (TTFields) is a non\u2010invasive therapeutic technology that disrupts mitotic division via intermediate\u2010frequency alternating electric fields. For non\u2010small cell lung cancer (NSCLC) at 150\u2009kHz, complex thoracic anatomy and heterogeneous tissue properties often hinder the attainment of the therapeutic threshold (\u2265\u20091\u2009V\/cm). To overcome this, high\u2010fidelity Duke (male) and Ella (female) anatomical models were employed for full\u2010wave simulations. The coordinated deployment of orthogonal transducer arrays (AP\u201020, LR\u201020, LR\u201013) with sex\u2010specific tuning substantially enhanced electric\u2010field coverage in the lower and lateral lung regions. Furthermore, modifying lung dielectric parameters by 20% demonstrated that these configurations maintain stable therapeutic coverage, exhibiting robustness against potential physiological or pathological variations. To provide an experimental foundation, in vivo murine measurements were conducted. Rather than attempting to replicate deep spatial complexities of the human body, these experiments served as a translational bridge to validate macroscopic voltage transfer efficiency and system\u2010level losses. By introducing a physically derived correction factor (Roi) to account for voltage delivery drops, statistical analyses confirmed a high agreement between simulated and in vivo datasets, verifying the reliability of the computational framework. Regarding safety, the computed electrode\u2013skin current density remained strictly below 31\u2009mA\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , which, alongside built\u2010in clinical hardware temperature limits, effectively mitigates the risk of thermal and stimulation\u2010induced injuries. Ultimately, this optimized strategy provides a complementary, independent physical modality that integrates bioelectromagnetic modeling with preclinical validation, offering a reliable theoretical reference to facilitate individualized NSCLC treatment planning.\n                  <\/jats:p>","DOI":"10.1002\/bem.70064","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:27:53Z","timestamp":1782466073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computational Simulation and Experimental Validation of Electric Field Distribution Patterns in TTFields Therapy for Lung Cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"Kairan","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Electrical Engineering Zhejiang University Hangzhou Zhejiang China"},{"name":"State Key Lab of Brain\u2010Machine Intelligence Zhejiang University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Healthy Life Innovation Medical Technology Co. Ltd. Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Lab of Brain\u2010Machine Intelligence Zhejiang University Hangzhou Zhejiang China"},{"name":"College of Biomedical Engineering &amp; Instrument Science Zhejiang University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Suo","sequence":"additional","affiliation":[{"name":"Jiangsu Healthy Life Innovation Medical Technology Co. Ltd. Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangsu Healthy Life Innovation Medical Technology Co. Ltd. Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9197-1421","authenticated-orcid":false,"given":"Xiaotong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Electrical Engineering Zhejiang University Hangzhou Zhejiang China"},{"name":"State Key Lab of Brain\u2010Machine Intelligence Zhejiang University Hangzhou Zhejiang China"},{"name":"Second Affiliated Hospital of School of Medicine Zhejiang University Hangzhou Zhejiang China"},{"name":"First Medical Center of the Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.04.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/2\/N01"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/41\/11\/003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-00773-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18046"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.09.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab33c6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702916104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-009-9262-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0083"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-25-0019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2023.101203"},{"issue":"92","key":"e_1_2_9_14_1","article-title":"Tumor Treating Field Therapy in Combination With Bevacizumab for the Treatment of Recurrent Glioblastoma","author":"Omar A. 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