{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:06:03Z","timestamp":1760216763772},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2002,6,21]],"date-time":"2002-06-21T00:00:00Z","timestamp":1024617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neural tube defects are one of the commonest human birth defects, with more than 0.5% of some populations affected. Mouse models are being used in an attempt to identify genes that could be involved in these malformations. Only two mouse mutations are known to lead to craniorachischisis, failure of closure of almost the entire neural tube. Two recent papers report that the gene for one of these, <jats:italic>Loop\u2010tail<\/jats:italic>, has now been identified and sequenced.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib1\">1<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib2\">2<\/jats:ext-link> It has been given the designation <jats:italic>Ltap\/Lpp1<\/jats:italic> and appears to function in floor plate formation. It will be of great interest to investigate the role of this gene in human neural tube defects. BioEssays 24:580\u2013583, 2002. \u00a9 2002 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bies.10120","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T11:32:01Z","timestamp":1033903921000},"page":"580-583","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of the mouse <i>Loop\u2010tail<\/i> gene: a model for human craniorachischisis?"],"prefix":"10.1002","volume":"24","author":[{"given":"Carolyn","family":"Kapron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/90081"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.22.2593"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a105976"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6638"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971212)73:2<113::AID-AJMG2>3.0.CO;2-V"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.109.2.243"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00196316"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420470112"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390211"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<292::AID-TERA10>3.0.CO;2-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900620207"},{"key":"e_1_2_1_13_2","first-page":"73","article-title":"Axial elongation in the mouse and its retardation in homozygous Loop\u2010tail mice","volume":"10","author":"Smith LJ","year":"1962","journal-title":"J Embryol Exp Morph"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1089"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/oxfordjournals.jhered.a106356","article-title":"Development of mice homozygous for the gene for Loop\u2010tail","volume":"44","author":"Stein KF","year":"1953","journal-title":"J Hered"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000147234"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(97)00099-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00029-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6493"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/383407a0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.18.3219"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00011-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/150.1.199"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.6.1149"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.15.2028"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370412"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370204"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.6.993"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1030"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(200005)61:5<347::AID-TERA6>3.0.CO;2-#"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.10120","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.10120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T14:24:28Z","timestamp":1700231068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.10120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,21]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1002\/bies.10120"],"URL":"https:\/\/doi.org\/10.1002\/bies.10120","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,21]]},"assertion":[{"value":"2002-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}