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Although it has been well established that IR exposure activates the ATM kinase domain, the actual mechanism by which ATM responds to damaged DNA has remained enigmatic. Now, a landmark paper provides strong evidence that DNA\u2010strand breaks trigger widespread activation of ATM through changes in chromatin structure.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib1\">1<\/jats:ext-link> This review discusses a checkpoint activation model in which chromatin perturbations lead to the conversion of inactive ATM domains to phosphorylated, active ATM monomers. The new findings underscore the critical importance of epigenetic events in genome function and surveillance in mammalian cells. BioEssays 25:627\u2013630, 2003. \u00a9 2003 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bies.10310","type":"journal-article","created":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T10:12:29Z","timestamp":1055758349000},"page":"627-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Checkpoint signaling: Epigenetic events sound the DNA strand\u2010breaks alarm to the ATM protein kinase"],"prefix":"10.1002","volume":"25","author":[{"given":"Robert T.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,6,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01368"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1664"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1011"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"TibbettsRS AbrahamRT.PI3K\u2010related kinases\u2014Roles in cell\u2010cycle regulation and DNA damage responses: signaling networks and cell cycle control: the molecular basis of cancer and other diseases.2000;5:267\u2013301.","DOI":"10.1385\/1-59259-218-X:267"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00159-3"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90225-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.914401"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3471"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1674"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.2307\/3578771"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/3578920"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/3579023"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300003200"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00386-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.10310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.10310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T20:34:04Z","timestamp":1700166844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.10310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,13]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/bies.10310"],"URL":"https:\/\/doi.org\/10.1002\/bies.10310","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,13]]},"assertion":[{"value":"2003-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}