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Molecular and biochemical analyses of <jats:italic>Hydra<\/jats:italic> ECM have established that it contains components similar to those seen in more complicated vertebrates such as human. In terms of biophysical parameters, <jats:italic>Hydra<\/jats:italic> ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. A more rigid ECM, as in vertebrates, would not be compatible with this degree of movement. The flexible nature of <jats:italic>Hydra<\/jats:italic> ECM can now be explained in part by the unique structure of the organism's collagens. Interestingly, some aspects of the structural features of <jats:italic>Hydra<\/jats:italic> collagens mimic what is seen in Ehlers\u2010Danlos syndrome, an inherited condition in humans that results in an abnormally flexible ECM that can be debilitating in extreme cases. This review will focus on structure\u2013function relationships of the ECM of <jats:italic>Hydra<\/jats:italic>. BioEssays 23:716\u2013724, 2001. \u00a9 2001 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/bies.1101","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:50:36Z","timestamp":1030312236000},"page":"716-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["<i>Hydra<\/i> and Niccolo Paganini (1782\u20131840)\u2014two peas in a pod? The molecular basis of extracellular matrix structure in the invertebrate, <i>Hydra<\/i>"],"prefix":"10.1002","volume":"23","author":[{"suffix":"Jr","given":"Michael P.","family":"Sarras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Deutzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,25]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Creativity and Disease. 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