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Recently several other polypeptides have been shown to catalyse poly(ADP\u2010ribose) formation. Poly(ADP\u2010ribosyl)ation is involved in a variety of physiological and pathophysiological phenomena. Physiological functions include its participation in DNA\u2010base excision repair, DNA\u2010damage signalling, regulation of genomic stability, and regulation of transcription and proteasomal function, supporting the previously observed correlation of cellular poly(ADP\u2010ribosyl)ation capacity with mammalian life. The pathophysiology effects are mediated through PARP\u20101 overactivity, which can cause cell suicide by NAD<jats:sup>+<\/jats:sup> depletion. It is apparent that the latter effect underlies the pathogenesis of a wide range of disease states including type\u20101 diabetes, ischaemic infarcts in various organs, and septic or haemorrhagic shock. Therefore pharmacological modulation of poly(ADP\u2010ribosyl)ation may prove to be an exciting option for various highly prevalent, disabling and even lethal diseases. BioEssays 23:795\u2013806, 2001. \u00a9 2001 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/bies.1115","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:56:46Z","timestamp":1030305406000},"page":"795-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":273,"title":["Physiology and pathophysiology of poly(ADP\u2010ribosyl)ation *"],"prefix":"10.1002","volume":"23","author":[{"given":"Alexander","family":"B\u00fcrkle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,8,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(63)90024-X"},{"key":"e_1_2_1_3_2","volume-title":"Poly (ADP\u2010Ribosylation) Reactions. 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