{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:03:52Z","timestamp":1791216232947,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Testis determination in most mammals is regulated by a genetic hierarchy initiated by the\n                    <jats:italic>SRY<\/jats:italic>\n                    gene. Early ovarian development has long been thought of as a default pathway switched on passively by the absence of\n                    <jats:italic>SRY<\/jats:italic>\n                    . Recent studies challenge this view and show that the ovary constantly represses male\u2010specific genes, from embryonic stages to adulthood. Notably, the absence of the crucial ovarian transcription factor FOXL2 (alone or in combination with other factors) induces a derepression of male\u2010specific genes during development, postnatally and, even more interestingly, during adulthood. Strikingly, in the adult, targeted ablation of\n                    <jats:italic>Foxl2<\/jats:italic>\n                    leads to a molecular transdifferentiation of the supporting cells of the ovary, which acquire cytological and transcriptomic characteristics of the supporting cells of the testes. These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions.\n                  <\/jats:p>","DOI":"10.1002\/bies.200900193","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T17:21:41Z","timestamp":1271956901000},"page":"375-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["FOXL2\n                    <i>versus<\/i>\n                    SOX9: A lifelong \u201cbattle of the sexes\u201d"],"prefix":"10.1002","volume":"32","author":[{"given":"Reiner 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