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Menin, a nuclear protein, interacts with wild\u2010type (WT) MLL, MLL\u2010FPs, and other partners such as the chromatin\u2010associated protein LEDGF and the transcription factor C\u2010Myb to promote leukemogenesis. The newly solved co\u2010crystal structure illustrating the menin\u2013MLL interaction, coupled with the role of menin in recruiting both WT MLL and MLL\u2010FPs to target genes, highlights menin as a scaffold protein and a central hub controlling this type of leukemia. The menin\/WT MLL\/MLL\u2010FP hub may also cooperate with several signaling pathways, including Wnt, GSK3, and bromodomain\u2010containing Brd4\u2010related pathways to sustain MLL\u2010FP\u2010induced leukemogenesis, revealing new therapeutic targets to improve the treatment of MLL\u2010FP leukemias.<\/jats:p>","DOI":"10.1002\/bies.201200007","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T12:15:48Z","timestamp":1343132148000},"page":"771-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Menin as a hub controlling mixed lineage leukemia"],"prefix":"10.1002","volume":"34","author":[{"given":"Austin 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