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The limbus acts as a \u2018reservoir\u2019 for limbal stem cells which maintain and regenerate the corneal epithelium. It also functions as a barrier to the conjunctiva and its blood vessels. Limbal stem cell deficiency is a general term for diseases which are characterised by the impairment of the limbus, limbal stem cells and their ability to replenish the corneal epithelium through proliferation and differentiation. Consequently, sufferers experience chronic pain and progressive blindness. This paper will highlight the salient milestones of limbal stem cell biology and potential future treatments for limbal stem cell deficiency.<\/jats:p>","DOI":"10.1002\/bies.201200086","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T14:01:44Z","timestamp":1352124104000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The limbal epithelium of the eye \u2013 A review of limbal stem cell biology, disease and treatment"],"prefix":"10.1002","volume":"35","author":[{"given":"Charles","family":"Osei\u2010Bempong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco C.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majlinda","family":"Lako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_8_2_2","volume-title":"Adler's Physiology of the Eye: Clinical Applications","author":"Kaufman PL","year":"2003"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0382"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181d39464"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.1.1.29"},{"key":"e_1_2_8_6_2","first-page":"1533","article-title":"Comparison of limbal and peripheral human corneal epithelium in tissue culture","volume":"29","author":"Ebato B","year":"1988","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.28.9.441"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.28.1.26"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/229560a0"},{"key":"e_1_2_8_10_2","first-page":"1442","article-title":"The X, Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft RA","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90958-6"},{"key":"e_1_2_8_12_2","first-page":"1962","article-title":"Kinetics of corneal epithelial maintenance and graft loss. 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