{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:53:19Z","timestamp":1779346399173,"version":"3.51.4"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:00:00Z","timestamp":1362528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has recently been shown that stem and progenitor cells undergo population self\u2010renewal to maintain epithelial homeostasis. The fate of individual cells is stochastic but the production of proliferating and differentiating cells is balanced across the population. This new paradigm, originating in mouse epidermis and since extended to mouse oesophagus and mouse and <jats:italic>Drosophila<\/jats:italic> intestine, is in contrast to the long held model of epithelial maintenance by exclusively asymmetric division of stem cells. Recent lineage tracing studies have now shown that wound responses vary between tissues, and that a stem cell reserve is not essential as cycling progenitors and even differentiating cells contribute to regeneration.<\/jats:p>","DOI":"10.1002\/bies.201200166","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T11:06:23Z","timestamp":1362567983000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cycling progenitors maintain epithelia while diverse cell types contribute to repair"],"prefix":"10.1002","volume":"35","author":[{"given":"David P.","family":"Doup\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,6]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.110.4.1001"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1979.tb01007.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90453-0"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90251-K"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001170106"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3902"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2302"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.09.014"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001060305"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb12437.x"},{"key":"e_1_2_10_12_2","first-page":"15","article-title":"Changes in location and orientation of mitotic figures in mouse oesophageal epithelium during the development of stratification","volume":"106","author":"Smart IH.","year":"1970","journal-title":"J Anat"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/226653a0"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/222881a0"},{"key":"e_1_2_10_16_2","first-page":"77","article-title":"The epidermal proliferative unit: the possible role of the central basal cell","volume":"7","author":"Potten CS.","year":"1974","journal-title":"Cell Tissue Kinet"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01447.x"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05574"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.76.021910"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1427"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.12.016"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001450102"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(84)80258-1"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/002203458106000311011"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00703"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11393"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.11.003"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.045"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1328"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00087.x"},{"key":"e_1_2_10_32_2","first-page":"4935","article-title":"Epidermal cell cycle and transit times during hyperplastic growth induced by abrasion or treatment with 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate","volume":"43","author":"Morris R","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000100102"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.11.013"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06196"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0421"},{"key":"e_1_2_10_37_2","first-page":"3860","article-title":"A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self\u2010renewal and lineage specification","volume":"118","author":"Kalabis J","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218835"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-12-18"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.08.034"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.6.1539"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf331"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.016"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196236"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1674008"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001410407"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09637"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.09.009"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.165"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213214"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10408"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.042"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013004108"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038965"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/333463a0"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224676"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2581"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.012"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2481"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-012-0422-8"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04371"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04333"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.07.020"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.106"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.048"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.10.004"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.014"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.026"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07329"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2012.04.002"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.065797"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.4161\/spmg.21763"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.05.017"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11344"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909738107"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.201200166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.201200166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:32:27Z","timestamp":1697056347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.201200166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,6]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1002\/bies.201200166"],"URL":"https:\/\/doi.org\/10.1002\/bies.201200166","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,6]]},"assertion":[{"value":"2013-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}