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In this article, we speculate on the intriguing possibility that a link remains between non\u2010visual opsins and neurohormonal systems that control neuronal circuit formation and activity in mammals. Historically, the retina and pineal gland were considered the only significant light\u2010sensing tissues in vertebrates. However over the last century, evidence has accumulated arguing that extra\u2010ocular tissues in vertebrates influence behavior through non\u2010image\u2010forming photoreception. One such class of extra\u2010ocular light detectors are the long mysterious deep brain photoreceptors. Here, we review recent findings on the cellular identity and the function of deep brain photoreceptors controlling behavior and physiology in zebrafish, and discuss their implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bies.201300034","type":"journal-article","created":{"date-parts":[[2013,5,26]],"date-time":"2013-05-26T11:24:41Z","timestamp":1369567481000},"page":"775-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Enlightening the brain: Linking deep brain photoreception with behavior and physiology"],"prefix":"10.1002","volume":"35","author":[{"given":"Ant\u00f3nio M.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Developmental Biology Unit Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandice","family":"Fero","sequence":"additional","affiliation":[{"name":"Program in Genomics of Differentiation Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Driever","sequence":"additional","affiliation":[{"name":"Developmental Biology Unit Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold A.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Program in Genomics of Differentiation Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01955345"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-08-02845.2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01680752"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00605532"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.08.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.041"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001142"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35003589"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014941107"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0pp00199f"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3689-12.2013"},{"key":"e_1_2_7_14_1","first-page":"607","article-title":"The system of cerebrospinal fluid\u2010contacting neurons. 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