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These include severe clinical symptoms, multiple animal hosts, and widespread vector species living in close proximity to human habitats, all of which constitute significant risk factors for more frequent outbreaks in the future, greatly increasing the potential of these hidden enemies to follow Zika and become the next wave of global arboviral threats. Critically, the current dearth of knowledge on these arboviruses might impede the success of future control efforts, including the potential application of<jats:italic>Wolbachia pipientis<\/jats:italic>. This bacterium inherently possesses broad anti\u2010pathogen properties and a means of genetic drive that allows it to eliminate or replace target vector populations. 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