{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:09:32Z","timestamp":1788628172160,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Widespread expression of the transcription factor, nuclear factor (erythroid\u2010derived 2)\u2010like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy\u2010induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide\u2010induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation\u2010induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging\u2010associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox\u2010associated HF disorders are therefore discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bies.201700029","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T12:10:52Z","timestamp":1499429452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Oxidative stress management in the hair follicle: Could targeting NRF2 counter age\u2010related hair disorders and beyond?"],"prefix":"10.1002","volume":"39","author":[{"given":"Laura","family":"Jadkauskaite","sequence":"first","affiliation":[{"name":"Centre for Dermatology Research School of Biological Sciences University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.","family":"Coulombe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and 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