{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:58:24Z","timestamp":1779170304850,"version":"3.51.4"},"reference-count":83,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF\u2010238\u20102013"],"award-info":[{"award-number":["ALTF\u2010238\u20102013"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cells mitigate the detrimental consequences of DNA damage on genome stability by attempting high fidelity repair. Homologous recombination templates DNA double\u2010strand break (DSB) repair on an identical or near identical donor sequence in a process that can in principle access the entire genome. Other physiological processes, such as homolog recognition and pairing during meiosis, also harness the HR machinery using programmed DSBs to physically link homologs and generate crossovers. A consequence of the homology search process by a long nucleoprotein filament is the formation of multi\u2010invasions (MI), a joint molecule in which the damaged ssDNA has invaded more than one donor molecule. Processing of MI joint molecules can compromise the integrity of both donor sites and lead to their rearrangement. Here, two mechanisms for the generation of rearrangements as a pathological consequence of MI processing are detailed and the potential relevance for non\u2010allelic homologous recombination discussed. Finally, it is proposed that MI\u2010induced crossover formation may be a feature of physiological recombination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bies.201700249","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T08:50:29Z","timestamp":1522054229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Multi\u2010Invasion\u2010Induced Rearrangements as a Pathway for Physiological and Pathological Recombination"],"prefix":"10.1002","volume":"40","author":[{"given":"Aur\u00e8le","family":"Piazza","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, One Shields Avenue, University of California Davis CA 95616 USA"},{"name":"Spatial Regulation of Genomes, Department of Genomes and Genetics, Institut Pasteur 25\u201028 Rue du Docteur Roux 75015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf\u2010Dietrich","family":"Heyer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Genetics, One Shields Avenue, University of California Davis CA 95616 USA"},{"name":"Department of Molecular and Cellular Biology, One Shields Avenue, University of California Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034352"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10782"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.12.027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.052"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12584"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.114.162297"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01987-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-010-0304-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1152"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp038"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.533810"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.534644"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006722"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711283114"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.11.032"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.086645"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012609"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300161"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2015.80.027649"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016428"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90331-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90191-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08868"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90270-9"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002305"},{"key":"e_1_2_9_28_1","unstructured":"M.\u2010C.Marsolier\u2010Kergoat M. M.Khan J.Schott X.Zhu B.Llorente bioRxiv2017."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28069"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005938"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3068"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.035"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07470"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00547-12"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023192"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619790114"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.177"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.08.011"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00343-5"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2359"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.09.007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.05.021"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.02.020"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.01.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.01.020"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.07.006"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb997"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005653"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.041"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016626"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00430-5"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.015"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aak9704"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90038-8"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00011-08"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2849"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2015.25"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2016.14.3.70"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.06.007"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a010397"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.40"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703856104"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.213"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183439"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.658"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.152454.112"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0074-4"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22171"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.035"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001228"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804529105"},{"key":"e_1_2_9_72_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/MMBR.63.2.349-404.1999","volume":"63","author":"P\u00e2ques F.","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.037"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07312"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv146"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22953"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.29"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1204-9"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02102862"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.7.3937"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002940000124"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.090233"},{"key":"e_1_2_9_83_1","first-page":"a022657","volume":"8","author":"Spies M.","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(03)00173-2"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.201700249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.201700249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:16:26Z","timestamp":1695539786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.201700249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":83,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/bies.201700249"],"URL":"https:\/\/doi.org\/10.1002\/bies.201700249","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732904570.793550419","asserted-by":"object"}]},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"2017-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1700249"}}