{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:23:01Z","timestamp":1762928581255,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis. Broadening the efficacy and durability of checkpoint inhibitors focuses on reversing tolerance and stimulating immunogenicity in the cancer, host, and environment. Two examples of important physiological states of tolerance that may inform tolerance of cancer are microbial infection and placental reproduction. These states of tolerance result from bilateral shaping of host and non\u2010self, akin to immunoediting in cancer, and offer reliable models to study the immune tolerance paradigm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bies.201800050","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T06:40:47Z","timestamp":1528180847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Understanding Immune Tolerance of Cancer: Re\u2010Purposing Insights from Fetal Allografts and Microbes"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-2716","authenticated-orcid":false,"given":"Megan B.","family":"Barnet","sequence":"first","affiliation":[{"name":"The Garvan Institute of Medical Research Darlinghurst 2010 NSW Australia"},{"name":"The Kinghorn Cancer Centre Darlinghurst 2010 NSW Australia"},{"name":"The Chris O'Brien Lifehouse Camperdown 2050 NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prunella","family":"Blinman","sequence":"additional","affiliation":[{"name":"Concord Cancer Centre Concord Repatriation General Hospital Concord 2139 NSW Australia"},{"name":"Sydney Medical School University of Sydney Camperdown 2050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Cooper","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney Camperdown 2050 Australia"},{"name":"Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital Camperdown 2050 NSW Australia"},{"name":"School of Medicine Western Sydney University Sydney 2050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Boyer","sequence":"additional","affiliation":[{"name":"The Chris O'Brien Lifehouse Camperdown 2050 NSW Australia"},{"name":"Sydney Medical School University of Sydney Camperdown 2050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kao","sequence":"additional","affiliation":[{"name":"The Chris O'Brien Lifehouse Camperdown 2050 NSW Australia"},{"name":"Sydney Medical School University of Sydney Camperdown 2050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Goodnow","sequence":"additional","affiliation":[{"name":"The Garvan Institute of Medical Research Darlinghurst 2010 NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050854"},{"volume-title":"Guns, Germs and Steel: The Fates of Human Societies","year":"1999","author":"Diamond J. M.","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2002.00113.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1983.0039"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/08828240260066198"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.9.1395"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2000.tb00007.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18848"},{"key":"e_1_2_8_11_1","unstructured":"J.Wargo \u201cModulating microbiome to improve responses\u201d presented at AACR Chicago 2018."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220961"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310861"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2693"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.01.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4972"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1329"},{"key":"e_1_2_8_16_2","unstructured":"b)L.Derosa B.Routy D.Enot G.Baciarello C.Massard Y.Loriot K.Fizazi B. J.Escudier L.Zitvogel L.Albiges in ASCO Genitourinary Cancers Symposium Orlando FL2017."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao3290"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4236"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan3706"},{"key":"e_1_2_8_18_1","unstructured":"L.Zitvogel \"In fluence of the microbiome on chemotherapy and immunotherapy \" presented at AACR Chicago 2018."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","volume":"46","author":"Belkaid Y.","journal-title":"Immunity"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414428"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175418"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1317"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0309"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1975.3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00408.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050019"},{"journal-title":"Cell. Mol. Immunol","year":"2017","author":"Zhang Y.","key":"e_1_2_8_28_1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1703047"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.143"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.696"},{"key":"e_1_2_8_31_2","doi-asserted-by":"crossref","unstructured":"b)S.Kovats E. K.Main C.Librach M.Stubblebine S. J.Fisher R.DeMars Science 1990 48 220;","DOI":"10.1126\/science.2326636"},{"key":"e_1_2_8_31_3","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0097"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5380.1191"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502615"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1966"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2671"},{"key":"e_1_2_8_35_1","first-page":"307","volume":"17","author":"Mullard A.","year":"2018","journal-title":"Nat. Rev. Drug Discov"},{"key":"e_1_2_8_36_1","unstructured":"Y.Zakharia in AACR American Association for Cancer Research Washington DC2017."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045481"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1829-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.25"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2034995100"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004731"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203486"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.06.003"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0879"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2750"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1995"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00878"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.201800050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.201800050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:19:47Z","timestamp":1694974787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.201800050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/bies.201800050"],"URL":"https:\/\/doi.org\/10.1002\/bies.201800050","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"type":"print","value":"0265-9247"},{"type":"electronic","value":"1521-1878"}],"subject":[],"published":{"date-parts":[[2018,6,4]]},"assertion":[{"value":"2018-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800050"}}