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BST\u20102 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST\u20102 anti\u2010viral function against respiratory viruses, how these viruses construct countermeasures to antagonize BST\u20102, and how BST\u20102 function might be targeted to develop therapies to treat respiratory virus infections. The authors address the current gaps in knowledge, including the need for mechanistic understanding of BST\u20102 antagonism by respiratory viruses, that should be bridged to achieve that goal.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bies.201800086","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T12:10:17Z","timestamp":1534421417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST\u20102\/Tetherin: Knowledge and Gaps"],"prefix":"10.1002","volume":"40","author":[{"given":"Kayla N.","family":"Berry","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Department of Internal Medicine Washington University School of Medicine St. Louis 63110 Missouri"},{"name":"Immunology Program Washington University School of Medicine St. Louis 63110 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