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CAR proteins are often found at tight junctions and interact with intracellular scaffolding proteins, suggesting that they might modulate tight junction assembly or function. However, impairment of tight junction integrity has not been reported in mouse knockout models or zebrafish mutants of CAR members. In contrast, in the same knockout models deficits in gap junction communication were detected in several organ systems, including the atrioventricular node of the heart, smooth muscle cells of the intestine and the ureter and in Sertoli cells of the testes. Possible interactions between BT\u2010IgSF and connexin41.8 on the disturbed pattern of pigment stripes found in zebrafish mutants and between ESAM and connexin43 during hematopoiesis in the mouse are also discussed. On the basis of the combined data and phenotypic similarities between CAR member mutants and connexin mutants I hypothesize that they primarily play a role in the organization of gap junction communication. Also see the video abstract here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/youtu.be\/i0yq2KhuDAE\">https:\/\/youtu.be\/i0yq2KhuDAE<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/bies.202000031","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T08:21:18Z","timestamp":1605082878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The CAR group of Ig cell adhesion proteins\u2013Regulators of gap junctions?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-613X","authenticated-orcid":false,"given":"Fritz G.","family":"Rathjen","sequence":"first","affiliation":[{"name":"Max\u2010Delbr\u00fcck\u2010Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.11.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1320"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3352"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02025-9"},{"key":"e_1_2_8_6_1","first-page":"525","article-title":"IGSF11 gene, frequently up\u2010regulated in intestinal\u2010type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM","volume":"23","author":"Katoh M. 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