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The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms\u2014for example, fish, salamanders, and embryonic\/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is exclusively limited to the low\u2010metabolic hearts of ectotherms. The biomedical field of regenerative medicine seeks to devise biologically inspired regenerative therapies to diseased human hearts. Falsification of the ectothermy dependency for heart regeneration hypothesis may be a crucial prerequisite to meaningfully seek inspiration in established ectothermic regenerative animal models. Otherwise, engineering approaches to construct artificial heart components may constitute a more viable path toward regenerative therapies. A more strict definition of regenerative phenomena is generated and several testable sub\u2010hypotheses and experimental avenues are put forward to elucidate the link between heart regeneration and metabolism. Also see the video abstract here <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/youtu.be\/fZcanaOT5z8\">https:\/\/youtu.be\/fZcanaOT5z8<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/bies.202000054","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T13:20:09Z","timestamp":1600953609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low\u2010Metabolic Ectotherms"],"prefix":"10.1002","volume":"42","author":[{"given":"Anita","family":"Dittrich","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine (Comparative Medicine Lab) Aarhus University  Aarhus N 8200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine (Comparative Medicine Lab) Aarhus University  Aarhus N 8200 Denmark"},{"name":"Department of Forensic Medicine Aarhus University  Aarhus N 8200 Denmark"},{"name":"Department of Biology (Zoophysiology) Aarhus University  Aarhus C 8000 Denmark"},{"name":"Leicester Royal Infirmary (East Midlands Forensic Pathology Unit) University of Leicester  Leicester LE2 7LX UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Irene Theilgaard","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine (Nuclear Medicine and PET) Aarhus University  Aarhus N 8200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Busk","sequence":"additional","affiliation":[{"name":"Department of Oncology (Experimental Clinical Oncology) Aarhus University Hospital  Aarhus N 8200 Denmark"},{"name":"Danish Centre for Particle Therapy Aarhus University Hospital  Aarhus N 8200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aage Kristian Olsen","family":"Alstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine (Nuclear Medicine and PET) Aarhus University  Aarhus N 8200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-4456","authenticated-orcid":false,"given":"Henrik","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine (Comparative Medicine Lab) Aarhus University  Aarhus N 8200 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_12_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.06.014"},{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","unstructured":"L.Spallanzani Prodromo di un\u2019 opera da imprimersi sopra le riproduzioni animali. 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