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Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual\u2010use gain\u2010of\u2010function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS\u2010CoV\u20102's distinctive spike\u2010protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re\u2010examination of the risks and rewards of dual\u2010use gain\u2010of\u2010function research.<\/jats:p>","DOI":"10.1002\/bies.202000091","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T21:56:24Z","timestamp":1597269384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Might SARS\u2010CoV\u20102 Have Arisen via Serial Passage through an Animal Host or Cell Culture?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9685-0338","authenticated-orcid":false,"given":"Karl","family":"Sirotkin","sequence":"first","affiliation":[{"name":"Karl Sirotkin LLC, 1301 Tadsworth Terrace  Lake Mary FL 32746 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