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Though many drugs have been proposed, none of them has shown particular efficacy in clinical trials. In this article, the relationship between the Adrenergic system and the renin\u2010angiotensin\u2010aldosterone system (RAAS) is focused in COVID\u201019 and a vicious circle consisting of the Adrenergic system\u2010RAAS\u2010Angiotensin converting enzyme 2 (ACE2)\u2010severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) (which is referred to as the \u201cARAS loop\u201d) is proposed. Hyperactivation of the ARAS loop may be the underlying pathophysiological mechanism in COVID\u201019, and beta\u2010adrenergic blockers are proposed as a potential treatment option. Beta\u2010adrenergic blockers may decrease the SARS\u2010CoV\u20102 cellular entry by decreasing ACE2 receptors expression and cluster of differentiation 147 (CD147) in various cells in the body. Beta\u2010adrenergic blockers may decrease the morbidity and mortality in COVID\u201019 patients by preventing or reducing acute respiratory distress syndrome (ARDS) and other complications. Retrospective and prospective clinical trials should be conducted to check the validity of the hypothesis. Also see the video abstract here <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/youtu.be\/uLoy7do5ROo\">https:\/\/youtu.be\/uLoy7do5ROo<\/jats:ext-link>.<\/jats:p>","DOI":"10.1002\/bies.202000094","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:08:17Z","timestamp":1598602097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Beta\u2010Adrenergic Blockers as a Potential Treatment for COVID\u201019 Patients"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-0662","authenticated-orcid":false,"given":"Natesan","family":"Vasanthakumar","sequence":"first","affiliation":[{"name":"School of Chemical and Biotechnology SASTRA Deemed University  Thanjavur Tamil Nadu 613401 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/situation-reports\/20200726-covid-19-sitrep-188.pdf?sfvrsn=f177c3fa_2(accessed: July 2020)."},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05985-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-020-09976-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"K.Wang W.Chen Y. 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