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ACE and vasoconstrictive AT1R clustered with the prorenin receptor. ACE2 and dilatory MAS1 clustered with nine RAS\u2010related genes, highly expressed in: Liver; Cardiac_Myocytes; Skeletal_Muscle; Uterus; Kidney; Lung; Small_Intestine; Smooth_Muscle.<\/jats:p><jats:p>RAS and stress accumulation: While prorenin is active after binding to its receptor, binding of soluble renin increases its enzymatic activity several times. Increased renin secretion multiplies the overall capacity for producing Ang I, leading to hypertension and increased vascular resistance.<\/jats:p><jats:p>Coronavirus infection and comorbidities: Cardiorespiratory failure during infection is linked to the previously altered RAS role in lungs and myocardium. Reduced vasodilation by ACE2 lead to vasoconstriction and suboptimal tissue perfusion patterns. Also see the video abstract here <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.youtube.com\/watch?v=Jf0Iped-Mws\">https:\/\/www.youtube.com\/watch?v=Jf0Iped-Mws<\/jats:ext-link><\/jats:p>","DOI":"10.1002\/bies.202000112","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T16:46:14Z","timestamp":1608309974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The renin\u2010angiotensin system in COVID\u201019: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?"],"prefix":"10.1002","volume":"43","author":[{"given":"Sven","family":"Kurbel","sequence":"first","affiliation":[{"name":"Medical Faculty Josip Juraj Strossmayer University of Osijek  Osijek Croatia"},{"name":"Medical Faculty Juraj Dobrila University of Pula  Pula Croatia"},{"name":"Polyclinic Aviva Zagreb  Zagreb Croatia"},{"name":"University of Applied Health Sciences  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2003.00518.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30243-7"},{"key":"e_1_2_9_5_1","volume-title":"Guyton And Hall Textbook Of Medical Physiology [13Th Ed.]","author":"Hall J.","year":"2016"},{"key":"e_1_2_9_6_1","volume-title":"Ganong's Review Of Medical Physiology","author":"Barrett K.","year":"2019"},{"key":"e_1_2_9_7_1","volume-title":"Medical Physiology","author":"Boron W. 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