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A few reports showing a positive correlation between BCG vaccination and reduced COVID\u201019 mortality have ushered in some hope. BCG has been suggested to confer a broad level of nonspecific protection against several pathogens, mainly via eliciting \u201ctrained immunity\u201d in innate immune cells. Secondly, BCG has also been proven to provide benefits in autoimmune diseases by inducing tolerogenicity. Being an acute inflammatory disease, COVID\u201019 requires a therapy that induces early priming of anti\u2010viral immune responses and regulates aberrant hyperactivity of innate\u2010immune cells. Here, we hypothesize that BCG can offer reliable spatiotemporal protection from COVID\u201019 by triggering trained immunity and tolerogenesis, through multiple cellular pathways. We propose further research on BCG\u2010mediated immunoprotection, especially in vulnerable individuals, as a strategy to halt the progress of the SARS\u2010CoV\u20102 pandemic. 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