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Neutrophils that are attracted to the site of infection secrete IL\u201017A, which stimulates lung epithelial cells to express CCL20. Natural Th17 (nTh17) cells are recruited to the infection site by CCL20 and expand in the presence of IL\u201023. These nTh17 cells are converted to T<jats:sub>RM<\/jats:sub> cells upon encounter with SARS\u2010CoV\u20102 and continue to exist as ex\u2010Th17 cells, which exert Th1\u2010like immunity during a memory response. G\u2010CSF can induce nTh17 cell accumulation at the infection site because it promotes neutrophil egress from the bone marrow. Hence, G\u2010CSF may be effective against COVID\u201019. Administration of G\u2010CSF to patients infected with SARS\u2010CoV\u20102 is worth a clinical trial.<\/jats:p>","DOI":"10.1002\/bies.202000232","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T12:29:36Z","timestamp":1604924976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can immunological manipulation defeat SARS\u2010CoV\u20102? 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