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In this article, an insight into one mechanism for the inactivation of these viruses by those two agents is presented, based on analysis of previous observations during electron microscopic examination of several members of the orthocoronavirinae subfamily, including the new virus SARS\u2010CoV\u20102. This inactivation is proposed to occur through Schiff base reaction\u2010induced conformational changes in the spike glycoprotein leading to its disruption or breakage, which can prevent binding of the virus to cellular receptors. Also, a new prophylactic and therapeutic measure against SARS\u2010CoV\u20102 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein. This measure needs to be confirmed experimentally before consideration. In addition, a new line of research is proposed to help find a broad\u2010spectrum antivirus against several members of this subfamily.<\/jats:p>","DOI":"10.1002\/bies.202000312","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T18:03:39Z","timestamp":1618596219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Can ketone bodies inactivate coronavirus spike protein? 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