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Lineage\u2010specific master transcription factors activate and repress gene expression by recruiting consistently expressed transcription factors and chromatin modifiers to their target loci. Recent technical advances in genome\u2010wide and multi\u2010omics analysis have shed light on unexpected mechanisms that underlie more complicated actions of transcription factors in cell fate decisions. In this review, we discuss functional dynamics of stably expressed and continuously required factors, Notch and Runx family members, throughout developmental stages of early T\u00a0cell development in the thymus. Pre\u2010 and post\u2010commitment stage\u2010specific transcription factors induce dynamic redeployment of Notch and Runx binding genomic regions. 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