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As the hair follicle exhibits unique immune\u2010modulatory properties, including the creation of an immunoinhibitory, immune\u2010privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of yeast and bacterial species, along with increasing proinflammatory sebum by\u2010products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune\u2010microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/youtu.be\/mEZEznCYtNs\">https:\/\/youtu.be\/mEZEznCYtNs<\/jats:ext-link><\/jats:p>","DOI":"10.1002\/bies.202100005","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T06:59:42Z","timestamp":1630911582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?"],"prefix":"10.1002","volume":"43","author":[{"given":"Susan L.","family":"Limbu","sequence":"first","affiliation":[{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Biomedical Research Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talveen S.","family":"Purba","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Biomedical Research Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Harries","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Biomedical Research Centre  Manchester UK"},{"name":"Salford Royal NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyu C.","family":"Wikramanayake","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Miteva","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit K.","family":"Bhogal","sequence":"additional","affiliation":[{"name":"Unilever R&amp;D Colworth Colworth Science Park  Sharnbrook UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Biomedical Research Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research University of Manchester &amp; NIHR Biomedical Research Centre  Manchester UK"},{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"},{"name":"Monasterium Laboratory  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"23","article-title":"The history of dandruff and dandruff in history. 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