{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:13:22Z","timestamp":1769768002262,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tyshkovskiy and Panchin have recently published a commentary on our paper in which they outline several \u201cpoints of disagreement with the Segreto\/Deigin hypothesis.\u201d As our paper is titled \u201cThe genetic structure of SARS\u2010CoV\u20102 does not rule out a laboratory origin,\u201d points of disagreement should provide evidence that rules out a laboratory origin. However, Tyshkovskiy and Panchin provide no such evidence and instead attempt to criticize our arguments that highlight aspects of SARS\u2010CoV\u20102 that could be consistent with the lab leak hypothesis. Strikingly, Tyshkovskiy and Panchin's main point of criticism is based on a false premise that we have claimed RaTG13 to be a direct progenitor of SARS\u2010CoV\u20102, and their other points of criticism are either not valid, based on flawed mathematical analysis, or are unrelated to our hypotheses. Thus, the genetic structure of SARS\u2010CoV\u20102 remains consistent with both natural or laboratory origin, which means that both the zoonotic and the lab leak hypothesis need to be investigated equally thoroughly.<\/jats:p>","DOI":"10.1002\/bies.202100137","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T05:12:51Z","timestamp":1627621971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The genetic structure of SARS\u2010CoV\u20102 is consistent with both natural or laboratory origin: Response to Tyshkovskiy and Panchin (10.1002\/bies.202000325)"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3397-5811","authenticated-orcid":false,"given":"Yuri","family":"Deigin","sequence":"first","affiliation":[{"name":"Youthereum Genetics Inc.  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-7042","authenticated-orcid":false,"given":"Rossana","family":"Segreto","sequence":"additional","affiliation":[{"name":"Department of Microbiology University of Innsbruck, Innsbruck, Tyrol  Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"The genetic structure of SARS\u2010CoV\u20102 does not rule out a laboratory origin","volume":"43","author":"Segreto R.","year":"2020","journal-title":"Bioessays"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000325"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr179"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10393-020-01503-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010146117"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-021-01211-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocontrol.2018.02.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5423\/PPJ.NT.12.2018.0306"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00656-19"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(97)01468-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011184"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202100137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bies.202100137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202100137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:04:37Z","timestamp":1693289077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.202100137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/bies.202100137"],"URL":"https:\/\/doi.org\/10.1002\/bies.202100137","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2021-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100137"}}