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It is hypothesized that coagulopathies accompanying SARS\u2010CoV\u20102 infections and vaccinations result from bacterial co\u2010infections that synergize with virus\u2010induced autoimmunity due to antigenic mimicry of blood proteins by both bacterial and viral antigens. Coagulopathies occur mainly in severe COVID\u201019 characterized by bacterial co\u2010infections with <jats:italic>Streptococci<\/jats:italic>, <jats:italic>Staphylococci<\/jats:italic>, <jats:italic>Klebsiella<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic>, and <jats:italic>Acinetobacter baumannii<\/jats:italic>. These bacteria express unusually large numbers of antigens mimicking human blood antigens, as do both SARS\u2010CoV\u20102 and adenoviruses. Bacteria mimic cardiolipin, prothrombin, albumin, and platelet factor 4 (PF4). SARS\u2010CoV\u20102 mimics complement factors, Rh antigens, platelet phosphodiesterases, Factors IX and X, von Willebrand Factor (VWF), and VWF protease ADAMTS13. Adenoviruses mimic prothrombin and platelet factor 4. Bacterial prophylaxis, avoidance of vaccinating bacterially infected individuals, and antigen deletion for vaccines may reduce coagulopathy risk. Also see the video abstract here: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/youtu.be\/zWDOsghrPg8\">https:\/\/youtu.be\/zWDOsghrPg8<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1002\/bies.202100158","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T15:20:56Z","timestamp":1634916056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["COVID\u201019 coagulopathies: Human blood proteins mimic SARS\u2010CoV\u20102 virus, vaccine proteins and bacterial co\u2010infections inducing autoimmunity"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-9306","authenticated-orcid":false,"given":"Robert","family":"Root\u2010Bernstein","sequence":"first","affiliation":[{"name":"Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006000"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00211-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101061"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.06.029"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001580"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04875-7"},{"issue":"19","key":"e_1_2_9_10_1","first-page":"1","article-title":"Immune thrombocytopenia secondary to COVID\u201019: A systematic review","author":"Bhattacharjee S.","year":"2020","journal-title":"SN Comprehensive Clinical Medicine"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.189"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15179"},{"key":"e_1_2_9_13_1","first-page":"n774","article-title":"Covid\u201019: AstraZeneca vaccine is not linked to increased risk of blood clots, finds European Medicine Agency","volume":"372","author":"Mahase E.","year":"2021","journal-title":"British Medical Journal (Clinical Research Edition)"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00107-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103474"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.04.027"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007214"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112392"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012938"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102792"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102663"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41425"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.584241"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd3876"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145168"},{"key":"e_1_2_9_26_1","article-title":"Is lupus anticoagulant a significant feature of COVID\u201019? 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