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Beginning with a selfish X chromosome, I propose a series of adaptations leading to this system, each compensating for deleterious consequences of the preceding adaptation: (1) YY embryonic inviability favored evolution of a selfish feminizing X chromosome; (2) the consequent Y chromosome transmission disadvantage favored X\u2010Y fusion (\u201cX<jats:sup>P<\/jats:sup>\u201d); (3) Xist\u2010based silencing of Y\u2010derived X<jats:sup>P<\/jats:sup> genes favored a second X\u2010Y fusion (\u201cX<jats:sup>M<\/jats:sup>\u201d); (4) X chromosome dosage\u2010related costs in X<jats:sup>P<\/jats:sup>X<jats:sup>M<\/jats:sup> males favored the evolution of X<jats:sup>M<\/jats:sup> loss during spermatogenesis; (5) X chromosomal dosage\u2010related costs in X<jats:sup>M<\/jats:sup>0 females favored the evolution of X<jats:sup>M<\/jats:sup> drive during oogenesis; and (6) degradation of the non\u2010recombining X<jats:sup>P<\/jats:sup> favored the evolution of biased X chromosome inactivation. I discuss recurrent rodent sex chromosome transformation, and selfish genes as a constructive force in evolution.<\/jats:p>","DOI":"10.1002\/bies.202100164","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T08:38:07Z","timestamp":1699519087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Did the creeping vole sex chromosomes evolve through a cascade of adaptive responses to a selfish x chromosome?"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6459","authenticated-orcid":false,"given":"Scott William","family":"Roy","sequence":"first","affiliation":[{"name":"San Francisco State University  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074347"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1970.0042"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130136"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5441.964"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.275274.121"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12111770"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.201665.115"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.03.029"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4159\/9780674029118"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esab020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2540.2001.00803.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ecolsys-021822-010659"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh1664"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071793"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0099"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.05.011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/3211856"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1890\/0012-9658(2006)87[1445:SOEFDD]2.0.CO;2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781400832019"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102343108"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.07.005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0364"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/35084545"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00326912"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6753153"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1988.0116"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080270211"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000129781"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2413264"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/1381612"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132544"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg7019"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-112414-055311"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/261225a0"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.1981.97"},{"volume-title":"Evolution of sex determining mechanisms","year":"1983","author":"Bull J. 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