{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:04:49Z","timestamp":1753862689085,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The causative agent of COVID\u201019 SARS\u2010CoV\u20102 has led to over 4 million deaths worldwide. Understanding the origin of this coronavirus is important for the prevention of future outbreaks. The dominant point of view that the virus transferred to humans either directly from bats or through an intermediate mammalian host has been challenged by Segreto and Deigin, who claim that the genome of SARS\u2010CoV\u20102 has certain features suggestive of its artificial creation. Following their response to our commentary, here we continue the discussion of the proposed arguments for this hypothesis. We show that neither the existence of a furin cleavage site in SARS\u2010CoV\u20102, nor the presence of specific sequences within the nucleotide insertion encoding that site are evidence for intelligent design. We also explain why existing genetic data, viral diversity and past human history suggest that a natural origin of the virus is the most likely scenario. Genetic evidence suggesting otherwise is yet to be presented.<\/jats:p>","DOI":"10.1002\/bies.202100194","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T07:04:03Z","timestamp":1635231843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["There is still no evidence of SARS\u2010CoV\u20102 laboratory origin: Response to Segreto and Deigin (10.1002\/bies.202100137)"],"prefix":"10.1002","volume":"43","author":[{"given":"Alexander","family":"Tyshkovskiy","sequence":"first","affiliation":[{"name":"Belozersky Institute of Physico\u2010Chemical Biology Moscow State University  Moscow Russia"},{"name":"Division of Genetics Department of Medicine Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Y.","family":"Panchin","sequence":"additional","affiliation":[{"name":"Sector of molecular evolution Institute for Information Transmission Problems Russian Academy of Sciences  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000240"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100137"},{"issue":"8","key":"e_1_2_8_4_1","first-page":"4558","article-title":"Bioinformatic analysis indicates that SARS\u2010CoV\u20102 is unrelated to known artificial coronaviruses","volume":"24","author":"Dallavilla T.","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06536"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01013-15"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"913","article-title":"Influenza in China in 1977: Recurrence of influenzavirus A subtype H1N1","volume":"56","author":"Kung H. C.","year":"1978","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/v4101878"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7463"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000325"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.017"},{"key":"e_1_2_8_12_1","unstructured":"Deigin Y.(2020).Lab\u2010Made? 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