{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:40:47Z","timestamp":1790422847955,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prokaryotes growing at high temperatures have a high proportion of charged residues in their proteins to stabilize their 3D structure. By mining 175 disparate bacterial and archaeal proteomes we found that, against the general trend for charged residues, the frequency of aspartic acid residues decreases strongly as natural growth temperature increases. In search of the explanation, we hypothesized that the reason for such unusual correlation is the deleterious consequences of spontaneous chemical transformations of aspartate at high temperatures. Our subsequent statistical analysis supported this hypothesis. This finding reveals that organisms have likely adapted to high temperatures by minimizing the harmful consequences of spontaneous chemical transformations.<\/jats:p>","DOI":"10.1002\/bies.202100213","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:09:42Z","timestamp":1637201382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aspartate\u2010phobia of thermophiles as a reaction to deleterious chemical transformations"],"prefix":"10.1002","volume":"44","author":[{"given":"Etienne","family":"Villain","sequence":"first","affiliation":[{"name":"Centre de Recherche en Biologie cellulaire de Montpellier UMR 5237 CNRS Universit\u00e9 de Montpellier 1919 Route de Mende  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Fort","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Biologie cellulaire de 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