{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:26Z","timestamp":1786977146416,"version":"build-2736575974"},"reference-count":140,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fibrillar protein aggregates are the pathological hallmark of a group of age\u2010dependent neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates of the microtubule\u2010associated protein Tau are observed in Alzheimer's disease and primary tauopathies. Tau pathology propagates from cell to cell in a prion\u2010like process that is likely subject to modulation by extracellular chaperones such as Clusterin. We recently reported that Clusterin delayed Tau fibril formation but enhanced the activity of Tau oligomers to seed aggregation of endogenous Tau in a cellular model. In contrast, Clusterin inhibited the propagation of \u03b1\u2010Synuclein aggregates associated with Parkinson's disease. These findings raise the possibility of a mechanistic link between Clusterin upregulation observed in Alzheimer's disease and the progression of Tau pathology. Here we review the diverse functions of Clusterin in the pathogenesis of neurodegenerative diseases, focusing on evidence that Clusterin may act either as a suppressor or enhancer of pathology.<\/jats:p>","DOI":"10.1002\/bies.202100287","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T08:09:24Z","timestamp":1651824564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The chaperone Clusterin in neurodegeneration\u2212friend or foe?"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-3849","authenticated-orcid":false,"given":"Patricia","family":"Yuste\u2010Checa","sequence":"first","affiliation":[{"name":"Department of Cellular Biochemistry Max Planck Institute of Biochemistry  Martinsried Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network  Chevy Chase Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-7594","authenticated-orcid":false,"given":"Andreas","family":"Bracher","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry Max Planck Institute of Biochemistry  Martinsried Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-135X","authenticated-orcid":false,"given":"F. Ulrich","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Cellular Biochemistry Max Planck Institute of Biochemistry  Martinsried Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"Aligning Science Across Parkinson's (ASAP) Collaborative Research Network  Chevy Chase Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100235\u20109"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010061516\u2010045115"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u20100333\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100238\u20106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010018\u20100011\u20104"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12481"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010072116\u2010031153"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003349\u20101"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27646"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24716"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2009.10.010"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010019\u20100777\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010072711\u2010163904"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025060\u20101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100319\u2010x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050976"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00164"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc\u20102015\u20100026"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162228299"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.381"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102011\u2010111844"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213503456"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)32238-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.6.2735"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366365"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003819\u20102"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003828\u20101"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa913"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560061007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06\u20107986com"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi5011249"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010017\u20100481\u20101"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201001079\u20101"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010018\u20100057\u20101"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.074"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi010135x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.1994.tb18807.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.02.018"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188500"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113531"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026366\u2010w"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38290-0"},{"issue":"4","key":"e_1_2_11_46_1","first-page":"369","article-title":"Predominant apolipoprotein J exists as lipid\u2010poor mixtures in cerebrospinal fluid","volume":"32","author":"Suzuki T.","year":"2002","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010019\u20100498\u20108"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.015"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100854.2007.00549.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252957"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.01.005"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00504"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051190"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203718666170918155247"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3112"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2191"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1080"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.689539"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000416\u20101"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868\u2010018\u20100402\u20107"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010021\u201000426\u20107"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701137114"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12660"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3103567"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181919a48"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296787"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050815"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa223"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100311\u20109"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.439"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.440"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010015\u20100024\u20109"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.17"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095152"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.07.005"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx329"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182605801"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26027"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.12.020"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.07.015"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.10.012"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160703180531"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100206\u20104"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.10.025"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190478"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013\u20101870"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cp05563b"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010019\u20100101\u2010y"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10948"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010017\u20100289\u2010z"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.7.1501"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13673"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318232a379"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003911\u20107"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.12.009"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593489"},{"key":"e_1_2_11_99_1","doi-asserted-by":"crossref","unstructured":"Wu S. Sirkis D. W. &Schekman R.(2022). Unconventional secretion of \u03b1\u2010synuclein mediated by palmitoylated DNAJC5 oligomers.bioRxiv. 2022.027.477991.https:\/\/doi.org\/10.1101\/2022.01.27.477991","DOI":"10.1101\/2022.01.27.477991"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.104"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103187"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.047"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2021.100242"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00160"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010014\u20100161\u2010z"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9490"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301440110"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102156\u20105"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00403"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009432"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010017\u20101722\u2010x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4132"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv081"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010016\u20100098\u2010z"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab122"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa090"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010021\u201002158\u20103"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg4980"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010011\u20100684\u20108"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201911126"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010010\u20100462\u2010z"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.529271"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw188"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2896"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5358"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600419"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.228213"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24219"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100715"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.056"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00456"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010020\u201000435\u2010y"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.11.013"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165\u20105728(94)00194\u2010s"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1994.1027"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2005.03065.x"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001456\u2010w"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010061010\u2010113810"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201002024\u20108"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/15.4.305"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202100287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bies.202100287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202100287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:01:31Z","timestamp":1692828091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.202100287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/bies.202100287"],"URL":"https:\/\/doi.org\/10.1002\/bies.202100287","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]},"assertion":[{"value":"2021-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100287"}}