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D\u2010cysteine binds to MARCKS and a host of proteins implicated in cell division and neurodevelopmental disorders. D\u2010cysteine decreases phosphorylation of MARCKS in neural progenitor cells (NPCs) affecting its translocation. D\u2010cysteine controls NPC proliferation by inhibiting AKT signaling. Exogenous D\u2010cysteine inhibits AKT phosphorylation at Thr 308 and Ser 473 in NPCs. D\u2010cysteine treatment of NPCs led to 50% reduction in phosphorylation of Foxo1 at Ser 256 and Foxo3a at Ser 253. We hypothesize that in the developing brain endogenous D\u2010cysteine is as a physiologic regulator of NPC proliferation by inhibiting AKT signaling mediated by Foxo1 and Foxo3a. Endogenous D\u2010cysteine may regulate mammalian neurodevelopment with roles in schizophrenia and Alzheimer's disease (AD).<\/jats:p>","DOI":"10.1002\/bies.202200002","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:10:04Z","timestamp":1651201804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mammalian D\u2010cysteine: A novel regulator of neural progenitor cell proliferation"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3851-4181","authenticated-orcid":false,"given":"Robin","family":"Roychaudhuri","sequence":"first","affiliation":[{"name":"Department of Neuroscience Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-7022","authenticated-orcid":false,"given":"Solomon 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