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The article focused on how epigenetic elements could return to their silent state, operationally defined as their epigenetic status before their modulation by experimental or environmental factors. Though Ringrose and Paro's article was on fruit flies and factors affecting embryological growth, the article asked a question of considerable importance to rapidly expanding research in neuroepigenetics on the correlation between trauma and neuropsychiatric risk: If you experience a traumatic event and, as a result, acquire an epigenetic trait that is considered pathological, can you free yourself of that trait? Ultimately, we are interested in how a return to silence is envisioned in neuroepigenetics research, how interventions purported to bring about that silence might function, and what this might mean for people who live in the aftermath of trauma.<\/jats:p>","DOI":"10.1002\/bies.202300019","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T11:22:29Z","timestamp":1683804149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Can you remember silence? Epigenetic memory and reversibility as a site of intervention"],"prefix":"10.1002","volume":"45","author":[{"given":"Stephanie","family":"Lloyd","sequence":"first","affiliation":[{"name":"Universit\u00e9 Laval  Qu\u00e9bec Canada"},{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Eric","family":"Lutz","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute  Montreal Quebec Canada"},{"name":"Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Int\u00e9gratives (UPR3212) 8 all\u00e9e du g\u00e9n\u00e9ral Rouvillois  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chani","family":"Bonventre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Les m\u00e9dications psychologiques: \u00c9tudes historiques, psychologiques et cliniques sur les m\u00e9thodes de la psychoth\u00e9rapie","author":"Janet P.","year":"1919"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.12.1530"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.1082"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04593-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09798"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.019"},{"issue":"1","key":"e_1_2_6_8_1","first-page":"245","article-title":"Suffering and the origins of traumatic memory","volume":"125","author":"Young A.","year":"1996","journal-title":"Daedalus"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511621765.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4177-6_4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0269889721000065"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40656-022-00542-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4000"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.667896"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06802-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508347112"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","unstructured":"Thumfart K. 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