{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:29:06Z","timestamp":1791408546018,"version":"4.3.3"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperbaric oxygen (HBO) therapy still lacks proper interpretations of its many actions. This hypothesis is based on reports of temporarily elevated peripheral vascular resistance (PVR) during HBO sessions. Besides that, during HBO sessions, hyperoxygenated tissues can reduce their perfusion so much that CO<jats:sub>2<\/jats:sub> can accumulate in them. Tissue perfusion depends on vascular innervation and on the balance between systemic constrictors and local dilators. During an HBO session, increased tissue oxygen levels suppress dilatory mechanisms. Tissue hyperoxygenation increases PVR, suggesting that the HBO action on an edematous tissue may be caused by an oxygen\u2010induced disbalance among Starling capillary forces. The presented hypothesis is that oxygen\u2010caused arteriolar constriction reduces the hydrostatic pressure in downstream capillaries. Thus, more tissue fluid is absorbed in vascular capillaries, under the condition that the plasma colloid osmotic pressure remains unaltered during the HBO session. Among several known mechanisms behind the HBO actions, the vasoconstriction has been listed as a therapeutic modality for the reduction of the tissue edema, for a crush injury, for burns (in an acute phase), and for the compartment syndrome. The Bell's palsy is among often listed indications for the HBO treatment, although evidence is poor and reports of randomized trials are scarce.<\/jats:p>","DOI":"10.1002\/bies.202300023","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:14:46Z","timestamp":1681283686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypothesis: Drainage of the peripheral tissue edema by the hyperbaric oxygen therapy because of hyperoxygenation that constricts arterioles and alters the downstream capillary fluid traffic in affected tissues"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-7254","authenticated-orcid":false,"given":"Sven","family":"Kurbel","sequence":"first","affiliation":[{"name":"Medical Faculty Josip Juraj Strossmayer University of Osijek  Osijek Croatia"},{"name":"Medical Faculty Juraj Dobrila University of Pula  Pula Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vid","family":"\u0106urkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Health Josip Juraj Strossmayer University of Osijek  Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borna","family":"Kova\u010di\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty Josip Juraj Strossmayer University of Osijek  Osijek Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"6","volume-title":"Hyperbaric oxygenation therapy: Molecular mechanisms and clinical applications","author":"Shinomiya N.","year":"2019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2020.06.004"},{"issue":"2","key":"e_1_2_8_4_1","article-title":"Hyperbaric oxygen therapy for Bell's palsy","volume":"2012","author":"Holland N. J.","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.06.016"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"67","article-title":"Effects of hyperbaric oxygen on ventricular performance, pulmonary blood volume, and systemic and pulmonary vascular resistance","volume":"27","author":"Abel F. L.","year":"2000","journal-title":"Undersea & Hyperbaric Medicine"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01197.2012"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"113","article-title":"The safety of hyperbaric oxygen treatment\u2013retrospective analysis in 2,334 patients","volume":"43","author":"Hadanny A.","year":"2016","journal-title":"Undersea and Hyperbaric Medicine"},{"key":"e_1_2_8_9_1","first-page":"7","volume-title":"Annales chirurgiae et gynaecologiae. Supplementum","author":"Korhonen K.","year":"2000"},{"key":"e_1_2_8_10_1","volume-title":"Guyton and Hall textbook of medical physiology e\u2010Book","author":"Hall J. E.","year":"2020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.2001.1288"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202300023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T19:03:05Z","timestamp":1692298985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.202300023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,12]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/bies.202300023"],"URL":"https:\/\/doi.org\/10.1002\/bies.202300023","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,12]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300023"}}