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The IPR is induced during infection with natural intracellular fungal and viral pathogens of the intestine and promotes resistance against these pathogens. Similarly, the IFN\u2010I response is induced by viruses and other intracellular pathogens and promotes resistance against infection. Whether the IPR and the IFN\u2010I response evolved in a divergent or convergent manner is an unanswered and exciting question, which could be addressed by further studies of immunity against intracellular pathogens in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    and other simple host organisms. Here we highlight similar roles played by RIG\u2010I\u2010like receptors, purine metabolism enzymes, proteotoxic stressors, and transcription factors to induce the IPR and IFN\u2010I response, as well as the similar consequences of these defense programs on organismal development.\n                  <\/jats:p>","DOI":"10.1002\/bies.202300097","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:44:51Z","timestamp":1693874691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Similarities in the induction of the intracellular pathogen response in\n                    <i>Caenorhabditis elegans<\/i>\n                    and the type I interferon response in mammals"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5825-6584","authenticated-orcid":false,"given":"Vladimir","family":"La\u017eeti\u0107","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of California, San Diego  La Jolla California USA"},{"name":"Department of Biological Sciences The George Washington University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-1858","authenticated-orcid":false,"given":"Lakshmi E.","family":"Batachari","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair B.","family":"Russell","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of California, San Diego  La Jolla California 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