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Emerging evidence indicates that such platelet\u2010derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet\u2010secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this early step of muscle regeneration exacerbates inflammation at later stages, compromises neo\u2010angiogenesis and the growth of newly formed myofibers, and reduces post\u2010injury muscle force production. Platelets also contribute to the recruitment of pro\u2010regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease.<\/jats:p>","DOI":"10.1002\/bies.202300134","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T14:47:48Z","timestamp":1694789268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Signaling roles of platelets in skeletal muscle regeneration"],"prefix":"10.1002","volume":"45","author":[{"given":"Flavia A.","family":"Graca","sequence":"first","affiliation":[{"name":"Department of Developmental Neurobiology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Minden\u2010Birkenmaier","sequence":"additional","affiliation":[{"name":"Department of Oncology Division of Molecular Oncology St. Jude Children's Research 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