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However, its biological role has not been elucidated until recent years. Despite of accumulated evidence that Ism1 participates in angiogenesis, tumor invasion, macrophage apoptosis, and glucose metabolism, the cognate receptors for Ism1 remain largely unknown.<jats:italic>Ism1<\/jats:italic>deficiency in mice results in renal agenesis (RA) with a transient loss of<jats:italic>Gdnf<\/jats:italic>transcription and impaired mesenchyme condensation at E11.5. Ism1 binds to and activates Integrin \u03b18\u03b21 to positively regulate Gdnf\/Ret signaling, thus promoting mesenchyme condensation and ureteric epithelium branching morphogenesis. Here, we propose the hypothesis underlying the mechanism by which Ism1 regulates branching morphogenesis during early kidney development.<\/jats:p>","DOI":"10.1002\/bies.202300189","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T04:34:17Z","timestamp":1704083657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Isthmin\u20101: A critical regulator of branching morphogenesis and metanephric mesenchyme condensation during early kidney development"],"prefix":"10.1002","volume":"46","author":[{"given":"Ge","family":"Gao","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute Medical Research Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Southern Medical University Guangzhou China"},{"name":"School of Biomedical Sciences LKS Faculty of Medicine The University of Hong Kong Hong Kong 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