{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:37:31Z","timestamp":1781649451506,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011776","name":"MND Scotland","doi-asserted-by":"publisher","award":["2023\/MNDS\/6400\/753TALB"],"award-info":[{"award-number":["2023\/MNDS\/6400\/753TALB"]}],"id":[{"id":"10.13039\/100011776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","award":["Talbot\/Apr22\/889\u2010791"],"award-info":[{"award-number":["Talbot\/Apr22\/889\u2010791"]}],"id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron\u2010centric mechanisms has recently shifted towards understanding the contribution of non\u2010neuronal cells, such as microglia, in ALS pathophysiology. Advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of iPSC\u2010derived microglia monocultures and co\u2010cultures to investigate their role in ALS pathogenesis. Here, we briefly review the insights gained from these studies into the role of microglia in ALS. While iPSC\u2010derived microglia monocultures have revealed intrinsic cellular dysfunction due to ALS\u2010associated mutations, microglia\u2010motor neuron co\u2010culture studies have demonstrated neurotoxic effects of mutant microglia on motor neurons. Based on these findings, we briefly discuss currently unresolved questions and how they could be addressed in future studies. iPSC models hold promise for uncovering disease\u2010relevant pathways in ALS and identifying potential therapeutic targets.<\/jats:p>","DOI":"10.1002\/bies.202400054","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T18:39:15Z","timestamp":1715107155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent insights from human induced pluripotent stem cell models into the role of microglia in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"46","author":[{"given":"Lara M.","family":"Nikel","sequence":"first","affiliation":[{"name":"Oxford Motor Neuron Disease Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford  Oxford UK"},{"name":"Dorothy Crowfoot Hodgkin Building, Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-1697","authenticated-orcid":false,"given":"Kevin","family":"Talbot","sequence":"additional","affiliation":[{"name":"Oxford Motor Neuron Disease Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford  Oxford UK"},{"name":"Dorothy Crowfoot Hodgkin Building, Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-5070","authenticated-orcid":false,"given":"Bj\u00f6rn F.","family":"Vahsen","sequence":"additional","affiliation":[{"name":"Oxford Motor Neuron Disease Centre Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford  Oxford UK"},{"name":"Dorothy Crowfoot Hodgkin Building, Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00487-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.01.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46695-w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.12.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41603-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq0651"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1179796"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16896-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.05.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad209"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.202400054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:14:03Z","timestamp":1719328443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.202400054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/bies.202400054"],"URL":"https:\/\/doi.org\/10.1002\/bies.202400054","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400054"}}