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The human X pericentromeric region contains genes potentially involved in meiotic mechanisms, including multiple <jats:italic>SPIN1<\/jats:italic> and <jats:italic>ZXDC<\/jats:italic> paralogs. This is consistent with a multigenic drive system comprising differential modification of the active and inactive X chromosome centromeres in female primordial germ cells and preferential segregation of the previously inactivated X chromosome centromere to the polar body at meiosis I. The drive mechanism may explain differences in X chromosome regulation in the female germlines of the human and mouse and, based on the functions encoded by the genes in the region, the transmission of X pericentromeric genetic or epigenetic variants to progeny could contribute to preeclampsia, autism, and differences in sexual differentiation.<\/jats:p>","DOI":"10.1002\/bies.202400056","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T07:30:06Z","timestamp":1722238206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["X centromeric drive may explain the prevalence of polycystic ovary syndrome and other conditions"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-9625","authenticated-orcid":false,"given":"Tom","family":"Moore","sequence":"first","affiliation":[{"name":"School of Biochemistry and Cell Biology University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2022.2484"},{"key":"e_1_2_10_3_1","unstructured":"Moore T. 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