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Recently, studies on the role of TEs and their dysregulation in cancers have shed light on the transcriptional, transpositional, and regulatory activity of TEs, revealing that the activation of developmental transcriptional programs by TEs may have a role in the dedifferentiation of cancer cells to the progenitor\u2010like cell states. This essay reviews the recent evidence of the <jats:italic>cis<\/jats:italic>\u2010regulatory TEs (henceforth crTE) in normal development and malignancy as well as the key transcription factors and regulatory pathways that are implicated in both cell states, and presents existing gaps remaining to be studied, limitations of current technologies, and therapeutic possibilities.<\/jats:p>","DOI":"10.1002\/bies.202400059","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T07:31:08Z","timestamp":1722238268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transposable elements as drivers of dedifferentiation: Connections between enhancers in embryonic stem cells, placenta, and 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