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While many studies have elucidated how TCR signaling and gene expression control T cell ontogeny, the role of nutrient metabolism is just emerging. Here, we discuss how metabolic reprogramming and nutrient availability impact the fate of developing thymic T cells. We focus on how the PI3K\/mTOR signaling mediates various extracellular inputs and how this signaling pathway controls metabolic rewiring during highly proliferative and anabolic developmental stages. We highlight the role of the hexosamine biosynthetic pathway that generates metabolites that are utilized for <jats:italic>N<\/jats:italic>\u2010 and <jats:italic>O<\/jats:italic>\u2010linked glycosylation of proteins and how it impacts TCR expression during T cell ontogeny. We consider the dichotomy in metabolic needs during \u03b1\u03b2\u2010 versus \u03b3\u03b4\u2010T cell lineage commitment as well as how metabolism is also coupled to molecular signaling that controls cell fate.<\/jats:p>","DOI":"10.1002\/bies.202400179","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T17:20:16Z","timestamp":1730913616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Food for thought: Nutrient metabolism controlling early T cell development"],"prefix":"10.1002","volume":"47","author":[{"given":"Guy","family":"Werlen","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Rutgers University, Robert Wood Johnson Medical School  Piscataway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and 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