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In conditions of low environmental temperature and scarce food resources, some endothermic animals enter a hypometabolic state known as torpor to conserve energy. Torpor involves a marked reduction in body temperature, heart rate, respiratory rate, and locomotor activity, enabling energy conservation. Despite their biological significance and potential medical applications, the neuronal mechanisms regulating torpor still need to be fully understood. Recent studies have focused on fasting\u2010induced daily torpor in mice due to their suitability for advanced neuroscientific techniques. In this review, we highlight recent advances that extend our understanding of neuronal mechanisms regulating torpor. We also discuss unresolved issues in this research field and future directions.<\/jats:p>","DOI":"10.1002\/bies.202400190","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:21:37Z","timestamp":1732688497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Art of Chilling Out: How Neurons Regulate Torpor"],"prefix":"10.1002","volume":"47","author":[{"given":"Akinobu","family":"Ohba","sequence":"first","affiliation":[{"name":"Department of Cell Physiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4323-1282","authenticated-orcid":false,"given":"Hiroshi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Multicellular Circuit Dynamics National Institute for Physiological Sciences Okazaki 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