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This hypervariable disease affects multiple systems, such as the musculoskeletal, central nervous, gastrointestinal, and others. Despite advances in understanding the underlying pathogenic mechanism of DM1, numerous gaps persist in our understanding, hindering elucidation of the heterogeneity and severity of its symptoms. Accumulating evidence indicates that the toxic intracellular RNA accumulation associated with DM1 triggers cellular senescence. These cells are in a state of irreversible cell cycle arrest and secrete a cocktail of cytokines, referred to as a senescence\u2010associated secretory phenotype (SASP), that can have harmful effects on neighboring cells and more broadly. We hypothesize that cellular senescence contributes to the pathophysiology of DM1, and clearance of senescent cells is a promising therapeutic approach for DM1. We will discuss the therapeutic potential of different senotherapeutic drugs, especially senolytics that eliminate senescent cells, and senomorphics that reduce SASP expression.<\/jats:p>","DOI":"10.1002\/bies.202400216","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T12:30:43Z","timestamp":1735216243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target"],"prefix":"10.1002","volume":"47","author":[{"given":"C\u00e9cilia","family":"L\u00e9gar\u00e9","sequence":"first","affiliation":[{"name":"RNA Institute College of Arts and Sciences University at Albany\u2010SUNY  Albany New York USA"},{"name":"School of Rehabilitation Sciences Faculty of Medicine Universit\u00e9 Laval  Quebec Quebec Canada"},{"name":"CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval Research Center  Qu\u00e9bec Qu\u00e9bec Canada"},{"name":"Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN) Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux du Saguenay\u2010Lac\u2010Saint\u2010Jean  Saguenay Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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