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Depending on the local microenvironment, MPs manifest considerably various lifespans and phenotypes to maintain tissue homeostasis. Vascular\u2010associated mononuclear phagocytes (VaMPs) are the special subsets of MPs that are localized either within the lumen side or on the apical surface of vessels, acting as the critical sentinels to recognize and defend against disseminated tumor cells. In this review, we introduce three major types of VaMPs, patrolling monocytes, Kupffer cells, and perivascular macrophages, and discuss their emerging roles in immunosurveillance during incipient metastasis. We also explore the roles of lineage\u2010determining transcription factors and cell surface receptors that endow VaMPs with potent anti\u2010tumor activity. Finally, we highlight the molecular and cellular mechanisms that drive the phenotypic plasticity of VaMPs and summarize combinatory strategies for targeting VaMPs in overt metastasis.<\/jats:p>","DOI":"10.1002\/bies.202400261","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T22:44:22Z","timestamp":1735512262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vascular\u2010Associated Mononuclear Phagocytes: First\u2010Line Soldiers Ambushing Metastasis"],"prefix":"10.1002","volume":"47","author":[{"given":"Han\u2010ying","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou P. R. 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