{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T16:22:49Z","timestamp":1702570969579},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T00:00:00Z","timestamp":1118620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rett syndrome (RTT) is an X\u2010linked dominant neurodevelopmental disorder affecting almost exclusively girls. Although mutations in methyl\u2010CpG\u2010binding protein (MeCP2) are known to be associated with RTT, gene expression patterns are not significantly altered in MeCP2\u2010deficient cells. A recent study<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib1\">1<\/jats:ext-link> identified MeCP2\u2010mediated histone modification and formation of a higher\u2010order chromatin loop structure specifically associated with silent chromatin at the <jats:italic>Dlx5\u2013Dlx6<\/jats:italic> locus in normal cells, and its absence thereof in RTT patients. This altered expression of <jats:italic>Dlx5<\/jats:italic> through loss of silent chromatin loop formation provides a molecular mechanism underlying RTT and proposes a novel role for MeCP2 in chromatin organization and imprinting. \u00a9 2005 Wiley Periodicals, Inc. BioEssays 27:676\u2013680, 2005. \u00a9 2005 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/bies.20266","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T17:48:04Z","timestamp":1118684884000},"page":"676-680","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association by guilt: identification of DLX5 as a target for MeCP2 provides a molecular link between genomic imprinting and Rett syndrome"],"prefix":"10.1002","volume":"27","author":[{"given":"Sharmila","family":"Bapat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Galande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1491"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00124.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10020"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg286"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10243"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.01.005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10008"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1200-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.7.487"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/426462"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1327"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2004.06.003"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.2.115"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.20.9248-9261.2004"},{"key":"e_1_2_1_16_2","first-page":"335","article-title":"Dlx5 regulates chondrocyte differentiation at multiple stages","volume":"47","author":"Bendall AJ","year":"2003","journal-title":"Int J Dev Biol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00177-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.1.245"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2003.10.004"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(02)00041-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.988402"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.07.007"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00276-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00586-9"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/85109"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190070501"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/345360"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0724-4"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/30764"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/561"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210256200"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1516"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.9.5656"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.5.1620-1633.2005"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01084"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbies.20266","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.20266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:19:53Z","timestamp":1700191193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.20266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,13]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1002\/bies.20266"],"URL":"https:\/\/doi.org\/10.1002\/bies.20266","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,13]]},"assertion":[{"value":"2005-06-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}