{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:44:02Z","timestamp":1775976242545,"version":"3.50.1"},"reference-count":106,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Visual systems appear like homogenous structures, where identical functional units repeat themselves across the eye. This architecture is thought to ensure a uniform sampling of the surrounding environment. Furthermore, anatomically and functionally identical properties of single units belonging to the same cell type, yet located across retinotopical positions are thought to ensure translational invariance. At the same time, regional differences and stochastic variations in microcircuit architecture have been linked to the processing of specific visual features. Recent access to connectomic datasets has revealed heterogeneity in visual circuitry that is at odds with these criteria: Cells considered to belong to the same type are variable in number and identity of connected partners, as well as in the relative number of synapses. This variable connectivity suggests that heterogeneous computations, even within defined cell types, is the rule, rather than the exception. It is therefore an exciting question whether these network properties increase functional variability, or even functional robustness, of visual processing.<\/jats:p>","DOI":"10.1002\/bies.70122","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:46Z","timestamp":1772989306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imprecision in Vision: Lessons From Neural Circuits in the Fly"],"prefix":"10.1002","volume":"48","author":[{"given":"Mathias F.","family":"Wernet","sequence":"first","affiliation":[{"name":"Fachbereich Biologie, Chemie &amp; Pharmazie Institut F\u00fcr Biologie \u2013 Neurobiologie  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Silies","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology and Neurobiology Johannes\u2010Gutenberg University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asd.2020.101012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.03.038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyad064"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010072116\u2010031335"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/nf\u20102017\u2010A028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.10.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16468"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21394"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045971\u2010z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068757\u2010x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.12.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024986\u2010w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50901"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-830-6_9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.021"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.10.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.054"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010vision\u2010032621\u2010075200"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008518\u20102"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2025.103035"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.01.079"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.12.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201017856\u20104"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26410"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.020"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1561"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.011"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008746\u20100"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57363-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-830-6"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.07.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300228"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010071013\u2010013931"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.09.061"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218858"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21966"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1567"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.02.075"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506763112"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007981\u20101"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007558\u2010y"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007686\u20105"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40025"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24394"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12450"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.019"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57443"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.09.680999"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1970.0012"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.04.047"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk3043"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903050206"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.5281\/ZENODO.13327244"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.05.024"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74937"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.12.038"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.029"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2005.06.038"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1556"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509820112"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.108529.1"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.014"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.05.024"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.08.010"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.01.061"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010021\u201001330\u20100"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809324-5.23904-7"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00016"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.022"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12597"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6727"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110145"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.010"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71858"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.04.068"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48935"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100029(19991215)47:6%3C368::AID\u2010JEMT2%3E3.0.CO;2\u2010Q"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0310\u201016.2016"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.028"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534\u20105807(03)00326\u20105"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(03)00848\u20101"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007967\u2010z"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63225"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3109\/01677063.2014.922556"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.07.020"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.103127"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.020"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695351"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00222228"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197653"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005317\u20105"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1339\u201024.2024"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010092920\u2010121538"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010674108"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13064\u2010018\u20100106\u20109"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17\u201004\u201001493.1997"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.046"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20104695(199907)40:1%3C77::AID\u2010NEU7%3E3.0.CO;2\u20100"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp9587"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.12.037"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010025\u201001937\u2010y"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147888"}],"container-title":["BioEssays"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.70122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bies.70122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bies.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T05:54:40Z","timestamp":1775973280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bies.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/bies.70122"],"URL":"https:\/\/doi.org\/10.1002\/bies.70122","archive":["Portico"],"relation":{},"ISSN":["0265-9247","1521-1878"],"issn-type":[{"value":"0265-9247","type":"print"},{"value":"1521-1878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}