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Recently, these pathways were shown to control a signalling rheostat that modulates chromosome replication and segregation fidelity in human pluripotent stem cells. In particular, WNT and BMP antagonists associated with embryo anteriorization during gastrulation (DKK1, Cerberus, LEFTY2, Noggin, and Chordin) induce DNA replication stress and damage in S\u2010phase leading to ultra\u2010fine\u2010bridges and whole\u2010chromosome mis segregation in the subsequent mitosis. Of note, aneuploidy in pre\u2010 and early post\u2010implantation embryos is the first cause of miscarriage in humans, and has also been associated with neurodevelopmental disorders. Here, we hypothesize that the antero\u2010posterior (A\u2013P) signalling gradient generates overlapping patterns of genome and chromosomal mosaicism in human embryos, with potential links to human infertility and lineage\u2010specific developmental disorders.<\/jats:p>","DOI":"10.1002\/bies.70128","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:43:18Z","timestamp":1774446198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphogen Gradients as Drivers of Mosaicism During Early Human Development"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-2497","authenticated-orcid":false,"given":"Sergio P.","family":"Acebr\u00f3n","sequence":"first","affiliation":[{"name":"University of the Basque Country (UPV\/EHU)  Leioa Spain"},{"name":"IKERBASQUE, Basque Foundation of Science  Bilbao Spain"},{"name":"Centre For Organismal Studies (COS) Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Hattemer","sequence":"additional","affiliation":[{"name":"Centre For Organismal Studies (COS) Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Rausch","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, European Molecular Biology Laboratory (EMBL)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-3676","authenticated-orcid":false,"given":"Anchel","family":"De Jaime\u2010Soguero","sequence":"additional","affiliation":[{"name":"Institut De Recherche Interdisciplinaire En Biologie Humaine Et Mol\u00e9culaire (IRIBHM) Jacques E. 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