{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:58:03Z","timestamp":1790780283499,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["MCB\u20102145083"],"award-info":[{"award-number":["MCB\u20102145083"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA308360"],"award-info":[{"award-number":["R01CA308360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioEssays"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Telomerase\u2010free cancer cells use a recombination\u2010based alternative lengthening of telomeres (ALT) pathway to maintain telomere length. ALT cancer cells exhibit extreme heterogeneity in telomere length, which requires the formation of a specialized nuclear condensate, the ALT telomere\u2010associated PML bodies (APBs). Recent findings on APB assembly reveal that APBs form through two mechanistically and kinetically distinct pathways. These pathways modulate the strength of ALT activity. In this essay, I discuss how APB formation dynamics may contribute to telomere\u2010length variability in ALT cells and consider the broader implications of these findings for other chromatin\u2010associated nuclear condensates.<\/jats:p>","DOI":"10.1002\/bies.70187","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:20:31Z","timestamp":1790778031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity"],"prefix":"10.1002","volume":"48","author":[{"given":"Huaiying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Carnegie Mellon University  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","article-title":"Hallmarks of Cancer\u2014Then and Now, and Beyond","volume":"189","author":"Hanahan D.","year":"2026","journal-title":"Cell"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1002\/j.1460-2075.1995.tb00098.x","article-title":"Telomere Elongation in Immortal Human Cells Without Detectable Telomerase Activity","volume":"14","author":"Bryan T. 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